Utility of minor determinants in penicillin allergy skin testing
نویسنده
چکیده
Background Penicillin allergy is a major concern among patients and physicians. There’s an estimated 5-10% self reported history of penicillin allergy by patients, but vast majority are not true hypersensitivities. Complete penicillin skin test with both major, minor determinants and amoxicillin is the test of choice for diagnosing IgE-mediated penicillin allergy. While Penicilloyl polylysine (major determinant) is widely available, the minor determinants of Penicilloate and Penilloate are not. The goal of this study is to investigate utility of using minor determinants to better detect IgE-mediated penicillin allergy.
منابع مشابه
Approach to Penicillin Allergy – A Survey
Individual approaches to the diagnosis and management of penicillin allergy are practiced by clinicians. This cross-sectional survey of physicians was aimed at exploring their ways of dealing with diagnosis and management of penicillin G allergy. Of the 235 respondents, 63% believed patients’ self-reported history of penicillin allergy and avoided using penic...
متن کاملUtility of penicillin allergy testing in patients presenting with a history of penicillin allergy
BACKGROUND Current statistics show that approximately 10% of patients claim to be allergic to penicillin yet only 10% of these have demonstrable allergy. The most appropriate and cost-effective antibiotics are sometimes withheld on the basis of patient history of drug allergy. OBJECTIVE Investigation of IgE hypersensitivity and delayed hypersensitivity in patients with a history of penicillin...
متن کاملA retrospective comparison of false negative skin test rates in penicillin allergy, using pencilloyl-poly-lysine and minor determinants or Penicillin G, followed by open challenge
BACKGROUND A history of penicillin allergy in patients is common, but only 10-15 % are truly allergic. While the gold standard for diagnosing penicillin allergy is challenge, it is not recommended that this be done without first carrying out diagnostic skin testing. This is carried out with the major determinant benzylpenicilloyl (PPL) and the minor determinant mixture (MDM), consisting of peni...
متن کاملDiagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing.
BACKGROUND Penicillin is no longer the most commonly prescribed beta-lactam, and the pattern of reactions has changed. We studied the diagnostic value of skin testing in penicillin-allergic subjects from a population where benzylpenicillin is not now the most frequently used beta-lactam. METHODS Patients with a history of immediate allergic reactions to penicillins were studied with: skin tes...
متن کاملApproach to Penicillin Allergy – A Survey
Individual approaches to the diagnosis and management of penicillin allergy are practiced by clinicians. This cross-sectional survey of physicians was aimed at exploring their ways of dealing with diagnosis and management of penicillin G allergy. Of the 235 respondents, 63% believed patients’ self-reported history of penicillin allergy and avoided using penicillin G; 97% do so for patients whos...
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